Metastasis Model
In Vivo Services
Metastasis Model Overview
In cancer research, metastasis models are crucial tools that help us understand how tumors migrate from their original location to other parts of the body. Ba/F3 cells are a common type of tumor cell, especially in mouse models, where they exhibit metastasis.
In our experimental case, the type of cells inoculated were Ba/F3-EGFR-Del19/T790M/C797S-Luc2 tumor cells. These cells, when subcutaneously inoculated, metastasize to the spleen. However, when inoculated via intraperitoneal injection, they primarily metastasize to the digestive system.
This pattern of metastasis provides a unique opportunity to study how tumors exploit different systems within the body for metastasis. For instance, by observing how Ba/F3-EGFR-Del19/T790M/C797S-Luc2 cells migrate from the subcutaneous inoculation site to the spleen, we can gain insights into how tumors utilize the circulatory system for metastasis. Similarly, by observing how these cells migrate from the intraperitoneal injection site to the digestive system, we can understand how tumors exploit the lymphatic system for metastasis.
In summary, these experimental models provide us with a valuable platform that can help us delve deeper into the biological characteristics of tumors and how they exploit various systems within the body for metastasis. This knowledge is crucial for developing new anticancer treatment strategies.
All in vivo Services
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The subcutaneous tumor model is one of the most commonly used in vivo evaluation systems for assessing the efficacy of novel anti-cancer drugs. Typically, tumor …
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